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Modern Methods of Total Synthesis

General data

Course ID: 1600-DUER1M
Erasmus code / ISCED: (unknown) / (0531) Chemistry The ISCED (International Standard Classification of Education) code has been designed by UNESCO.
Course title: Modern Methods of Total Synthesis
Name in Polish: Modern Methods of Total Synthesis
Organizational unit: Faculty of Chemistry
Course groups:
ECTS credit allocation (and other scores): 0 OR 4.00 (depends on study program) Basic information on ECTS credits allocation principles:
  • the annual hourly workload of the student’s work required to achieve the expected learning outcomes for a given stage is 1500-1800h, corresponding to 60 ECTS;
  • the student’s weekly hourly workload is 45 h;
  • 1 ECTS point corresponds to 25-30 hours of student work needed to achieve the assumed learning outcomes;
  • weekly student workload necessary to achieve the assumed learning outcomes allows to obtain 1.5 ECTS;
  • work required to pass the course, which has been assigned 3 ECTS, constitutes 10% of the semester student load.

view allocation of credits
Language: English
Prerequisits:

Knowledge of structures, properties and reactivity of mono- and polyfunctionalized organic compounds, functional group transformations, mechanisms of ionic and radical organic reactions as well as concerted processes.

Short description:

Modern methods of organic synthesis applied in multistep preparation of more complex materials from the group of so-called natural products and their biologically active analogues will be discussed. The lecture include basic aspects of the retrosynthetic analysis, novel tools and methods applied in the synthesis of naturally occurring organic materials and detailed analysis of the reaction steps in the total syntheses of the selected compounds.

Learning outcomes:

By the end of the course student:

- indicates major goals, methods and tools of the total synthesis of natural products

- defines key synthetic steps of retrosynthetic analysis of selected compounds

- describes new methods for the carbon-carbon bond forming reactions including catalytic cross-couplings, metathesis, carboanion-induced transformations and radical processes

- suggests alternative synthetic routes towards selected polyfunctionalized organic compounds

- discusses on advanced organic chemistry problems in English

- is aware of significance of self-education

Classes in period "Winter Semester 2024/2025" (future)

Time span: 2024-10-01 - 2025-02-16
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: (unknown)
Students list: (inaccessible to you)
Examination: (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

Feeding methods: lecture, multimedia presentation

Activating methods: classroom discussion


Method and Criteria of Assessment:

Credit (required participation in at least 85% of the lectures) and Written exam

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents


Bibliography:

1. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

2. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

3. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

4. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

Classes in period "Winter Semester 2023/2024" (past)

Time span: 2023-10-01 - 2024-02-25
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: Marcin Jasiński
Students list: (inaccessible to you)
Examination: (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

Feeding methods: lecture, multimedia presentation

Activating methods: classroom discussion


Method and Criteria of Assessment:

Credit (required participation in at least 85% of the lectures) and Written exam

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents


Bibliography:

1. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

2. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

3. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

4. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

Classes in period "Winter Semester 2022/2023" (past)

Time span: 2022-10-01 - 2023-02-19
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: Marcin Jasiński
Students list: (inaccessible to you)
Examination: (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

Feeding methods: lecture, multimedia presentation

Activating methods: classroom discussion


Method and Criteria of Assessment:

Credit (required participation in at least 85% of the lectures) and Written exam

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents


Bibliography:

1. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

2. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

3. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

4. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

Classes in period "Winter Semester 2021/2022" (past)

Time span: 2021-10-01 - 2022-01-23
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: Marcin Jasiński
Students list: (inaccessible to you)
Examination: (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

Feeding methods: lecture, multimedia presentation

Activating methods: classroom discussion


Method and Criteria of Assessment:

Credit (required participation in at least 85% of the lectures) and Written exam

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents


Bibliography:

1. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

2. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

3. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

4. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

Classes in period "Winter Semester 2020/2021" (past)

Time span: 2020-10-01 - 2021-02-07
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: Marcin Jasiński
Students list: (inaccessible to you)
Examination: Course - (in Polish) Ocena zgodna z regulaminem studiów
Examination - (in Polish) Ocena zgodna z regulaminem studiów
Lecture - (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

feeding methods - problem lecture with the elements of multimedia presentations; seeking methods - discussion

Method and Criteria of Assessment:

attendance at >85% lectures and passing one written test

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents.

Bibliography:

[1]. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

[2]. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

[3]. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

[4]. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

Classes in period "Winter Semester 2019/2020" (past)

Time span: 2019-10-01 - 2020-02-23
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: Marcin Jasiński
Students list: (inaccessible to you)
Examination: Course - (in Polish) Ocena zgodna z regulaminem studiów
Examination - (in Polish) Ocena zgodna z regulaminem studiów
Lecture - (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

feeding methods - problem lecture with the elements of multimedia presentations; seeking methods - discussion

Method and Criteria of Assessment:

attendance at >85% lectures and passing one written test

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents.

Bibliography:

[1]. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

[2]. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

[3]. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

[4]. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

Classes in period "Winter Semester 2018/2019" (past)

Time span: 2018-10-01 - 2019-02-10
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: Marcin Jasiński
Students list: (inaccessible to you)
Examination: Course - (in Polish) Ocena zgodna z regulaminem studiów
Examination - (in Polish) Ocena zgodna z regulaminem studiów
Lecture - (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

feeding methods - problem lecture with the elements of multimedia presentations; seeking methods - discussion

Method and Criteria of Assessment:

attendance at >85% lectures and passing one written test

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents.

Bibliography:

[1]. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

[2]. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

[3]. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

[4]. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

Classes in period "Winter Semester 2017/2018" (past)

Time span: 2017-10-01 - 2018-02-09
Selected timetable range:
Navigate to timetable
Type of class:
Examination more information
Lecture, 28 hours more information
Coordinators: Marcin Jasiński
Group instructors: Marcin Jasiński
Students list: (inaccessible to you)
Examination: Course - (in Polish) Ocena zgodna z regulaminem studiów
Examination - (in Polish) Ocena zgodna z regulaminem studiów
Lecture - (in Polish) Ocena zgodna z regulaminem studiów
(in Polish) Czy IRK BWZ?:

(in Polish) T

Teaching Method:

feeding methods - problem lecture with the elements of multimedia presentations; seeking methods - discussion

Method and Criteria of Assessment:

attendance at >85% lectures and passing one written test

Course Content:

- biological activity of the selected organic compounds,

- methods for the isolation of the natural products,

- design and tools for the organic synthesis,

- protecting groups, chemoselective transfromations,

- phase transfer catalysis,

- olefin metathesis,

- anion relay chemistry,

- methods for the formation of new C-C bonds,

- organometallic reagents.

Bibliography:

[1]. T. Hudlicky, J. W. Reed, The Way of Synthesis: Evolution of Design and Methods for Natural Products Wiley-VCH, Weinheim 2007.

[2]. K. C. Majumdar, S. K. Chattopadhyay, Heterocycles in Natural Products, Wiley-VCH, Weinheim 2011.

[3]. K. C. Nicolaou, J. S. Chen, Classics In Total Synthesis III, Wiley-VCH, Weinheim 2011.

[4]. Original papers and review articles published in such journals as Angewandte Chemie, Journal of the American Chemical Society, Organic Letters, Tetrahedron, Chemical Reviews.

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